The siPOOL Guide: The Pack Hunter Approach to Superior Gene Silencing. Clean, Reliable & Hassle-free RNAi.

A detailed guide with an introduction to the RNAi off-target problem and how siPOOLs were developed to counter them. Covers the three main features of siPOOLs - high complexity pooling, detailed bioinformatics-based design and quality production process - and the benefits they confer. Includes proof-of-concept data, customer testimonials and case study applications. Download The siPOOL Guide

The siPOOL Human Kinase Library

siPOOLs are ideal for reliable high-throughput functional genomic screening. Learn more about the siPOOL human kinase library, the screening benefits it confers and associated data in this brochure. Download brochure.

The siPOOL Cancer Toolbox

The siPOOL cancer toolbox is a useful exploratory tool for scientists seeking an easy method to disrupt key cancer genes singly or in combination. Download brochure.

The Phenovault

The Phenovault is a free-access data analysis and reagent/gene evaluation tool that leverages new insights based on historical RNAi/CRISPR screening data. Download brochure.

siPOOL-resistant rescue construct/sequence

Further validation of gene function can be done by performing siPOOL rescue experiments. Learn more.

Technical Notes

Technote 1: siRNA Off-target Effects - Causes, Extent & Impact

Learn about siRNA off-target effects. A reference-rich guide describing the mechanism by which siRNA off-targets are produced, the penetrance and extent of siRNA off-target effects, and the impact siRNA off-targets have on experimental research.

Download Technote 1: siRNA Off-target Effects - Causes, Extent & Impact