These heparin oligosaccharides have been made from high quality heparin modified by standard chemical methods to selectively remove the sulphate groups. The oligosaccharides are prepared using bacterial heparinases and isolated by high resolution gel filtration.
4 variations of selectively desulphated heparin oligosaccharides are available, dp4 dp12:
2-O-desulphated heparin oligosaccharides Sulphate group removed from the C2 of iduronate
6-O-desulphated heparin oligosaccharides Sulphate group removed from the C6 of glucosamine
N-desulphated heparin oligosaccharides Sulphate group removed from the N sulphate of the glucoasmine
N-desulphated re N-acetylated heparin oligosaccharides The free amino group (NH+3) in N-desulphated heparin has been modified by acetylation