Chondroitinase B from Flavobacterium heparinum. This enzyme is produced via a dedicated preparation and is not a heparinase by-product.
The enzymatic degradation of dermatan sulphate.
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Chondroitinase AC-1 degrades chondroitin sulphates A and C but is not active on dermatan sulphate (chondroitin sulphate B).
The package size for the Chondroitinase AC enzymes is defined in International Units (IU) – one international unit is “the amount of enzyme that will liberate 1.0 μmole of product per minute from chondroitin sulphate substrate at 25º C” (Product is unsaturated saccharides)
Chondroitinase AC-1 cleaves sulphated and non-sulphated polysaccharides regions of CS A and CS C yielding mostly disaccharides and fewer oligosaccharides containing unsaturated uronic acids, detectable by UV spectroscopy (232 nm).